TABLE 1.

Obsessive-Compulsive Disorder Severity Over 4 weeks (N = 9)

				Ketamine	10 Hours of CBT				Follow-Up
Participant	Age	BDNF Genotype*	Baseline YBOCS	↓	Week 1 YBOCS	% Change	Week 2 YBOCS	% Change	Week 3 YBOCS	% Change	Week 4 YBOCS	% Change
1	55	Val/Val	27		4	85.2†	3	88.9†	2	92.6†	3	88.9†
2	25	Val/Val	29		16	44.8†	14	51.7†	15	48.3†	18	37.9†
3	39	Val/Val	27		18	33.3	16	40.7†	17	37†	17	37†
4	33	Val/Val	35		30	14.3	34	2.9	33	5.7	33	5.7
5	36	Val/Val	21		18	14.3	13	38.1†	19	9.5	21	0
6	20	Val/Val	30		15	50.0†	22	26.7	29	3.3	31	−3.3
7	32	Met/Met	33		19	42.4†	19	42.4†	23	30.3	22	33.3
8	40	Met/Met	34		24	29.4	24	29.4	28	17.6	30	11.8
9‡	32	Met/Val	28		34	−21.4	—	—	—	—	—	—

^*Val66Met haplotype in the BDNF gene.

^†Responders (in bold type) with at least 35% change from baseline.

^‡Because of increased OCD symptoms, participant did not complete 10 hours of CBT.

Met indicates methionine; Val, valine.