Table 3. Severity of clinical signs in ferrets infected with influenza viruses.
Virus | Weight loss | Activity loss | Temperature | Nasal inflammation | Total Score | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein | Cell | |||||||||||
Placebo | OST | Placebo | OST | Placebo | OST | Placebo | OST | Placebo | OST | Placebo | OST | |
Influenza A | ||||||||||||
H1N1 | 1 | 0 | 3 | 1 | 1 | 1 | 3 | 0 | 2 | 1 | 10 | 3 |
H1N1(H275Y) | 1 | 1 | 2 | 3 | 3 | 2 | 2 | 0 | 1 | 1 | 9 | 7 |
H1N1pdm09 | 3 | 0 | 3 | 1 | 3 | 2 | 3 | 2 | 3 | 1 | 15 | 6 |
H1N1pdm09(H275Y) | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 15 | 15 |
H3N2 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 2 | 0 | 4 | 1 |
H3N2(E119V) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influenza B | ||||||||||||
B | 0 | 0 | 1 | 1 | 2 | 0 | 1 | 1 | 0 | 1 | 3 | 3 |
B(D197N) | 0 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 1 | 0 | 4 | 1 |
B(H273Y) | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |