Table 7.
Areas of uncertainty, knowledge gaps and barriers in implementation of multigene panel testing for colorectal cancer
| Areas of uncertainty, knowledge gaps and barriers in multigene panel testing for colorectal cancer |
|---|
| Optimal panel of genes not established |
| Risk estimates and management for low- and moderate-penetrance genes uncertain |
| Increased number of variants of uncertain significance |
| Utility of simultaneous somatic and germline genetic testing not establisheda |
| Lack of access, resources & education |
a
Except for evaluation of double somatic mismatch repair variants in tumors