Figure 7.

Synaptic recruitment of muscarinic AChRs suppresses PF. Recordings were conducted in slices of ChAT-ChR2-EYFP mice. A, Loose-patch recording from a TRN neuron showing brief barrage of ACh-evoked activity (black), which is prolonged following application of the mAChR antagonist atropine (10 μm, blue). B, Raster plot of ACh-evoked neuronal activity before and following atropine application, for the cell shown in A. C, Summary data quantifying the average duration of ACh-evoked action potential activity before and after atropine application (n = 5). *p < 0.05.