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. 2020 Jun 17;40(25):4881–4887. doi: 10.1523/JNEUROSCI.0581-20.2020

Figure 1.

Figure 1.

Adolescent MK-801 exposure reduces the frequency of IPSC onto prefrontal pyramidal neurons. a, MK-801 exposure during adolescence (black arrows, P35–P40) diminished the frequency of IPSC recorded from layer V pyramidal neurons in the PFC. Relative to saline-treated controls (n = 19), the IPSC frequency in MK-801-treated rats remained reduced through adulthood from P70–P90 (n = 14) to P95–P125 (n = 9; ***p < 0.001 vs saline, unpaired t test). A similar reduction in miniature IPSC (mIPSC) was found between saline-treated (n = 8) and MK-801-treated (n = 12) groups (***p < 0.001 vs saline, unpaired t test). b, In contrast, the frequency of IPSC recorded from rats that received MK-801 during adulthood (black arrows, P75–P80; n = 11) resembled that of saline-treated controls (n = 7). Similarly, the frequency of mIPSC remained unchanged following adult MK-801 exposure (n = 7–8/group). c, Example traces of IPSC recorded from layer V pyramidal neuron illustrating the age-dependent impact of MK-801. Calibration: 20 pA, 500 ms.