Figure 6.

Prefrontal infusions of Indiplon normalized the behavioral deficit elicited by adolescent MK-801 treatment. a, Diagram of coronal brain sections illustrating all PFC infusion sites of aCSF and Indiplon (10 μm). All PFC infusions were performed 20–25 min prior to behavioral testing. b, Data summarizing the acquisition of trace fear conditioning from adolescent MK-801-treated rats assigned to receive either aCSF (n = 9) or Indiplon (n = 8) on the next day. c, Relative to aCSF controls, PFC infusion of Indiplon significantly improved the fear extinction performance and reduced the percentage of freezing (main effect of PFC infusion: F_(1,105) = 35.6, ***p < 0.0001; two-way ANOVA), in particular from trials 7–14 (*p < 0.05, **p < 0.005, Tukey's post hoc test). The extinction profile of saline-treated controls (gray line) shown in Figure 5b was included for comparison.