Figure 5. The roles of the LINC01268/miR-217/SOS1 axis in acute myeloid leukemia (AML) cells. After HL-60 and Kasumi-1 cells were transfected with si-LINC01268+miR-217 inhibitor, si-LINC01268+NC (negative control) inhibitor, or si-NC+ NC inhibitor, (A) the cell viability was detected by CCK-8 assay; (B and C) the cell cycle and apoptosis were measured by flow cytometry; and (D) the protein expression of SOS1, CDK4, p21, Bax, Bcl-2, and cleaved caspase-3 were evaluated by western blot. Data are reported as means±SD. **P<0.01 vs the control group (ANOVA and t-test).
