Table 2.
Coagulation parameters
| Standard reference range, or measurements from the control cohort (n=13) | ICU (n=48) | Non-ICU (n=20) | p value | |
|---|---|---|---|---|
| D-dimer, mg/L FEU | <0·55 | 4·2 (2·6–6·9) | 0·7 (0·4–1·2) | <0·0001 |
| TAT, μg/L | <4 | 10·6 (7·1–18·4) | 7·2 (4·7–11·3) | 0·020 |
| Antithrombin activity | 70–133% | 102% (32) | 111% (13) | 0·12 |
| Protein C activity | 81–145% | 121% (97–150) | 106% (92–130) | 0·46 |
| Protein S activity | 62–166% | 100% (30) | 93% (22) | 0·32 |
| α2-antiplasmin activity | 72–122% | 112% (24) | 113% (10) | 0·77 |
| PAI-1, ng/mL | 4–43 | 58 (47–88) | 54 (44–89) | 0·65 |
| VWF antigen | 62–175% | 565% (199) | 278% (133) | <0·0001 |
| VWF activity | 58–163% | 390% (390–390) | 260% (145–323) | <0·0001 |
| Factor VIII activity | 66–143% | 398% (111) | 251% (90) | <0·0001 |
| Soluble P-selectin, ng/mL* | 9·5 (8·5–11·3)† | 15·9 (4·8) | 11·2 (3·1) | 0·0014 |
| Soluble thrombomodulin, ng/mL* | 2·5 (2·2–3·3)† | 4·2 (2·6–6·5) | 3·0 (2·6–3·2) | 0·23 |
| sCD40L, pg/mL* | 67 (33–98)† | 136 (82–228) | 157 (85–211) | 0·80 |
Data are mean (SD) or median (IQR), unless specified otherwise. p values are for comparison between ICU and non-ICU patients. ICU=intensive care unit. FEU=fibrinogen equivalent units. TAT=thrombin-antithrombin complex. PAI-1=plasminogen activator inhibitor-1. VWF=von Willebrand factor. sCD40L=soluble CD40 ligand.
*
Measured in 40 ICU and ten non-ICU patients.
†
Median values measured in the control cohort (n=13).