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The genomic structure of coronaviruses. (A) Classification of coronavirus, with the new coronavirus SARS-CoV-2 highlighted in red. (B) The genome structure of four genera of coronaviruses. Pp1a and pp1b represent the 2 long polypeptides that are processed into 16 nonstructural proteins. S, E, M, and N indicate the four structural proteins spike, envelope, membrane, and nucleocapsid proteins.
