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. 2020 Jun 30;31(13):107838. doi: 10.1016/j.celrep.2020.107838

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© 2020 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Ultrastructural Analysis of Atrx-cKO^Male CA1 Apical Synapses

(A) Representative images of Ctrl^Male and Atrx-cKO^Male CA1 synapses imaged by transmission electron microscopy. Red indicates presynaptic bouton, and the postsynaptic spine is blue. Scale bar, 200 nm.

(B) Number of vesicles in 50-nm bins from the active zone (p = 0.95).

(C) Number of total vesicles (p < 0.01).

(D) Density of vesicles per cluster (p < 0001).

(E) Number of docked vesicles (p < 0.05).

(F) Area of the postsynaptic density (PSD) (p < 0.005).

(G) Synaptic cleft width (p < 0.0001).

(H) Length of the presynaptic active zone (p = 0.70).

(I) Synaptic vesicle cluster size (p = 0.99).

(J) Vesicle diameter (p = 0.19).

All of the data in (B)–(J) were obtained from 104 Ctrl^Male synapses and 84 Atrx-cKO^Male synapses from 3 brains of each genotype. The data were analyzed by unpaired Student’s t test (C–J) or 2-way repeated-measures ANOVA with Sidak’s multiple comparisons test (B). The data are displayed as means ± SEMs in (B)–(J).