Figure 4.

Atrx-cKO^Male Mice Display Deficits in the Paired-Associate Operant Task

(A) Representative images used in the paired-associate learning task, in which touching the (+) stimuli on the screen results in reward and the (−) stimuli results in negative reinforcement (Talpos et al., 2009).

(B) Percentage correct over 10 weeks (p < 0.005). Dotted line indicates percentage correct by chance.

(C) Number of correction trials required over 10 weeks (p < 0.0001).

(D) Latency to choose a correct answer (p = 0.49).

(E) Latency to choose an incorrect answer (p = 0.72).

(F) Latency to retrieve the reward (p = 0.33).

(G) Number of days to reach criterion in the visual paired discrimination (VPD) task (p < 0.01).

(H) Percentage correct during baseline (2 days) and reversal (10 days) (p = 0.25).

(I) Number of correction trials required during baseline and reversal trials (p < 0.005).

For the PAL task, n = 13 Ctrl^Male and n = 16 Atrx-cKO^Male mice. For the VPD task, n = 14 Ctrl^Male and n = 15 Atrx-cKO^Male mice. Statistics by 2-way repeated-measures ANOVA with Sidak’s multiple comparisons test were applied in all of the panels, except for (G), in which Student’s t test was applied. Asterisks indicate p < 0.05. See also Videos S1 and S2.