Figure 6.

WT and Gnat2^−/− mice with lens defocus show significant correlations with axial elongation and myopic refractions. (A) WT and (B) Gnat2^−/− mice without lens defocus showed significant positive correlation for axial length versus refractive error across all ages tested. These trends can be explained by the normal developmental growth of the eye while the refractive error became more hyperopic with age. (C) WT LIM mice housed in white light showed a significant negative correlation such that longer axial lengths correlated with more myopic refractions. In contrast, WT LIM mice housed in green or violet light did not have significant correlations between axial length and refractive error. Thus, treatment groups with the largest myopic shift (white light) showed the greatest correlations between axial elongation and refractive error. (D) Likewise, in Gnat2^−/− LIM mice, all light group showed significant negative correlations and large myopic shifts.