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Contribution plot from the OPLS-DA model including all metabolites. According to the plot, glycine, glutamate, leucine, serine, piperidine, valine, and tryptophan were considered important; citrulline, C3DC, and homocysteine were slightly below the “important” threshold. Metabolites to the right of homocysteine were unimportant in contributing to the OPLS-DA model. All metabolites analyzed in current study obtained positive contribution scores, which indicated higher levels in ROP.
