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. 2020 Jun 18;9:e59264. doi: 10.7554/eLife.59264

Figure 2. Evolution of rRNA domain III reduction.

Figure 2.

Comparison of H48-60 rRNA between E. coli and mitochondria of T. thermophila and H. sapiens. Left, LSU model with rRNA is shown in gray and domain III is highlighted, conserved proteins are in blue, shared mitoribosomal proteins are in red, and specific mitoribosomal proteins are in yellow. Right, schematic representation of the rRNA region subjected to reduction. In H. sapiens, the rRNA deletions are structurally restabilized by proteins mL37 and mL65. In T. thermophila, the rRNA reduction is less severe, and flexible elements such as H56 have no binding protein partners, suggesting an intermediate stage between E. coli and H. sapiens.