Figure 5.

VGB attenuates the amplitude of later scotopic OP wavelets in mice. In VGB-treated mice (open circles), although OP1 and OP2 amplitudes were not significantly different (A, B), the DA 1 cd*s/m² OP3 amplitude was decreased in VGB-treated mice (filled circles) compared with time-matched controls at 4 weeks of VGB treatment (C). The OP4 amplitude was attenuated in VGB-treated mice at 2, 4, and 8 weeks of VGB treatment (D). Implicit times of OP wavelets were not significantly different between groups (A–D). Representative waveforms from both right and left eyes shown for one control and one VGB-treated mouse (E). DA, dark adapted. *P < .05; **P < .01; ***P < .001.