FIGURE 4.

Meta-analysis of the association between LA biomarkers and mortality from all causes, CVD, and cancer. Squares represent pooled RRs from random-effects inverse-variance–weighted meta-analyses, and horizontal lines represent 95% CIs. We present summary RRs and 95% CIs for each tissue and all tissue combined. ¹The total study number is not the sum of study numbers for each of the tissues. This is because the MRFIT study (59) provided data on LA in phospholipid and cholesteryl ester for the same population; we used both data in the meta-analysis by tissue types but chose to use LA in phospholipid in the overall meta-analysis. Detailed forest plots presenting association estimates from each study and meta-analyses are provided in Supplemental Figure 2. CVD, cardiovascular disease; LA, linoleic acid; MRFIT, Multiple Risk Factor Intervention Trial.