Table 3.
Cox proportional hazards regression analyses for cardiovascular outcome within 1500 days follow-up.
| Univariable Regression |
Multivariable Regression |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Model 1 (I-PRESERVE) |
Model 2 |
||||||||
| Variable | HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value |
| Age (years) | 1.01 | 1.00–1.03 | 0.031 | 1.01 | 0.99–1.02 | 0.075 | 1.00 | 0.99–1.02 | 0.433 |
| Male sex (yes) | 0.90 | 0.73–1.17 | 0.453 | ||||||
| BMI (kg/m2) | 0.96 | 0.93–1.00 | 0.091 | ||||||
| Previous hospitalization for HF (yes) | 1.62 | 1.19–2.21 | 0.002 | 1.42 | 1.02–1.99 | 0.036 | 1.47 | 0.97–2.24 | 0.068 |
| NYHA III or IV (yes) | 1.80 | 1.33–2.43 | <0.001 | 1.16 | 0.78–1.73 | 0.453 | |||
| Diabetes mellitus (yes) | 1.14 | 0.87–1.49 | 0.327 | 1.26 | 0.96–1.66 | 0.94 | |||
| Hypertension (yes) | 0.77 | 0.57–1.03 | 0.083 | ||||||
| Dyslipidemia (yes) | 0.99 | 0.72–1.36 | 0.977 | ||||||
| IHD (yes) | 1.04 | 0.80–1.34 | 0.740 | ||||||
| Atrial fibrillation (yes) | 1.18 | 0.89–1.59 | 0.237 | ||||||
| SBP (mm Hg) | 1.00 | 0.99–1.00 | 0.877 | ||||||
| DBP (mm Hg) | 0.99 | 0.98–1.00 | 0.126 | ||||||
| Hemoglobin (g/dL) | 0.87 | 0.81–0.93 | <0.001 | 0.90 | 0.83–0.99 | 0.033 | |||
| hs-CRP (mg/L) | 1.02 | 0.97–1.07 | 0.422 | ||||||
| eGFR (mL/min/1.73 m2) | 1.00 | 0.97–1.01 | 0.351 | ||||||
| ln-BNP | 1.16 | 1.05–1.28 | 0.003 | 1.08 | 0.96–1.20 | 0.160 | 1.01 | 0.88–1.16 | 0.823 |
| LVEF (%) | 0.99 | 0.97–1.01 | 0.552 | ||||||
| SVI (L/min) | 0.99 | 0.98–1.00 | 0.555 | ||||||
| LAD (mm) | 1.01 | 1.00–1.03 | 0.047 | 1.00 | 0.98–1.02 | 0.690 | |||
| E/e′ | 1.02 | 0.99–1.04 | 0.082 | ||||||
| TR-PG (mm Hg) | 1.01 | 0.99–1.03 | 0.124 | ||||||
| PAP (mm Hg) | 1.01 | 1.00–1.03 | 0.018 | 1.01 | 0.95–1.02 | 0.175 | |||
| Diuretics (yes) | 1.48 | 1.12–1.95 | 0.005 | 1.09 | 0.75–1.59 | 0.629 | |||
| ACE-I or ARB (yes) | 1.07 | 0.82–1.40 | 0.578 | ||||||
| CCB (yes) | 0.90 | 0.69–1.16 | 0.437 | ||||||
| Beta-blocker (yes) | 0.96 | 0.74–1.24 | 0.792 | ||||||
| Statin (yes) | 1.05 | 0.80–1.38 | 0.714 | ||||||
| CONUT score | 1.16 | 1.08–1.24 | <0.001 | 1.14 | 1.06–1.22 | <0.001 | 1.12 | 103–1.21 | 0.005 |
Model 1: age, previous hospitalization for HF, diabetes mellitus, ln-BNP and CONUT score.
Model 2: variables of statistical significance in the univariable analyses (P < 0.05).
Abbreviations as shown in this table. HR: hazard ratio CI: confidence interval ln-BNP: natural logarithmic transformed B-type natriuretic peptide level