Table 2.
circRNAs Involved in Cardiovascular Diseases
| Diseases | circRNAs | Method | +/− | Axis | Effects | Samples | Ref. |
|---|---|---|---|---|---|---|---|
| IMI | circNCX1 | Sanger sequencing | + | circNCX1-miR-133a-3p-CDIP1 | promotes cardiomyocyte apoptosis | fetal cardiomyocyte-derived H9c2 cell | 87 |
| MF | circRNA_010567 | circRNA-array | + | circRNA_010567-miR-141-TGF-β1 | promotes Col I, Col III, and α-SMA expression | diabetic mice myocardium and CFs treated with Ang II | 88 |
| MF | circRNA_000203 | circRNA-array | + | circRNA_000203-miR-26b-5p-Col1a2 and CTGF | promotes the expression of Col1a2 and CTGF and promotes myocardial fibrosis | myocardium of the db/db mice | 31 |
| CH and HF | HRCR/(mm9-circ-012559) | N/A | − | HRCR-miR-223-ARC | overexpression of HRCR can decrease cardiomyocyte size, WH/WB, cardiac stress gene expression, and interstitial fibrosis | mouse heart | 84 |
| AMI | circRNA_081881 | circRNA-array | − | circRNA_081881-miR-548-PPARγ | as a potential target for the diagnosis and treatment of AMI | plasma of AMI patients | 89 |
IMI, ischemic myocardial injury; MF, myocardial fibrosis; CFs, mouse cardiac fibroblasts; CH and HF, cardiac hypertrophy and heart failure; WH/WB, heart weight to body weight ratio; AMI, acute myocardial infarction; circRNA-array, circRNA microarray; N/A, not available; +, upregulate; −, downregulate.