Table 3.

circRNAs Involved in Other Diseases

Diseases	circRNAs	Method	+/−	Axis	Effects	Samples	Ref.
SNI	circRNA.2837	HT RNA-seq	−	circRNA.2837-miR-34 family-LC3-II/p62	protects neurons against injury by inducing autophagy	ISN of rats	90
NI	mmu-circRNA-015947	circRNA-array	+	mmu-circRNA-015947-mmu-miR-(188-3p, 329-5p, 3057-3p, 5098, 683)	may be involved in the process of IRI	HT22 cells with OGD/R	91
AD	ciRS-7	N/A	−	ciRS-7-miRNA-7-UBE2A	regulates the downregulation of UBE2A expression	human AD brain tissues	93,94
PD	circDLGAP4	N/A	−	circDLGAP4-miR-134-5p-CREB signaling	inhibits viability, induces apoptosis, increases mitochondrial damage, attenuates autophagy, and thereby increases the neurotoxic effects	MPTP-induced PD mouse model and MPP+-induced PD cell models	102
OA	mmu-circRNA-30365; mmu-circRNA-36866	HT RNA-seq			new molecular targets for treatment of OA	IL-1β-induced MACs	24
OA	circRNA_Atp9b	N/A	+	circRNA_Atp9b-miR-138-5p-type II collagen/MMP13/IL-6 and COX-2	knockdown of circRNA_Atp9b increases the synthesis of type II collagen, reduces the expression of MMP13, IL-6, and COX-2	IL-1β-induced MACs	27
OA	circRNA-MSR	circRNA-array	+	circRNA-MSR-miR-875-TNF-α	silencing of circRNA-MSR will downregulated TNF-α and increase ECM formation	knee joint tissues of patients	103
OA	circRNA-CER	circRNA-array	+	circRNA-CER-miR-136-MMP13	silencing of circRNA-CER will downregulate MMP13 expression and increase ECM formation	knee joint tissues of OA patients	104
DM	circHIPK3	N/A	+	circHIPK3-miR-30a-VEGFC/Wnt2/FZD4	silencing circHIPK3 can alleviate retinal vascular dysfunction	human and mouse retinal endothelial cells	105

SNI, sciatic nerve injury; ISN, injured sciatic nerve; NI, neuron injury; IRI, cerebral ischemia-reperfusion injury; OGD/R, oxygen-glucose deprivation/reoxygenation; AD, Alzheimer’s disease; PD, Parkinson’s disease; OA, osteoarthritis; MACs, mouse articular chondrocytes; ECM, extracellular matrix; RA, rheumatoid arthritis; T2DM, type 2 diabetes mellitus; DM, diabetes mellitus; HT RNA-seq, high-throughput RNA sequencing; circRNA-array: circRNA microarray; N/A, not available; +, upregulate; −, downregulate; COX-2, cyclooxygenase 2.