Table 4.
Circulating circRNA Acted as a Potential Biomarker for Diseases
| Diseases | circRNAs | Method | + /− | Samples | Ref. |
|---|---|---|---|---|---|
| GC | circ-KIAA1244 | circRNA-array | − | plasma of GC patients | 108 |
| GC | hsa_circ_0000520 | circRNA-array | − | plasma of GC patients | 109 |
| GC | circ_0009910 | N/A | + | plasma of GC patients | 110 |
| LAC | hsa_circ_0005962; hsa_circ_0086414 | N/A | plasma of LAC patients | 111 | |
| CRC | hsa_circ-0004771 | N/A | + | exosomes from serum of CRC patients | 112 |
| BC | hsa_circ_0001785 | circRNA-array | PB of BC patients | 113 | |
| UCB | circPRMT5 | circRNA-array | + | UCB tissues, exosome purification, serum, and urine | 78 |
| CHD | hsa_circRNA_004183, hsa_circRNA_079265, and hsa_circRNA_105039 | circRNA-array | − | plasma of children with CHD | 114 |
| CAD | hsa_circ_0124644 | circRNA-array | + | PB of CAD patients | 83 |
| AMI | MICRA | N/A | − | PB of AMI patients | 85,115 |
| RA | hsa_circRNA (104194, 104593, 103334, 101407, and 102594) | circRNA-array | PBMC of RA patients | 28 | |
| RA | circRNAs (092516, 003524, 103047, 104871, and 101873) | circRNA-array | + | PBMC of RA patients | 103 |
| RA | hsa_circ_0044235 | circRNA-array | − | PB of RA patients | 117 |
| T2DM | hsa_circ_0054633 | circRNA-array | PB of T2DM patients | 29 | |
| TB | hsa_circRNA_001937 | circRNA-array | + | PBMC of TB patients | 45 |
GC, gastric adenocarcinoma; LAC, lung adenocarcinoma; CRC, colorectal cancer; BC, breast cancer; UCB, urothelial carcinoma of the bladder; CHD, congenital heart disease; CAD, coronary artery disease; AMI, acute myocardial infarction; RA, rheumatoid arthritis; T2DM, type 2 diabetes mellitus; TB, tuberculosis; PB, peripheral blood; PBMC, peripheral blood mononuclear cell; circRNA-array, circRNA microarray; N/A, not available; +, upregulate; −, downregulate.