TABLE 3.

List of selective studies using organic-inorganic nanoparticles for the delivery of therapeutics for the repair of myocardial infracted heart tissue.

Nanoparticles/size (nm)	Therapeutic agents	MI Model	Dose/administration route	Results	References
DNAzyme-conjugated AuNPs/14± 3	Silence TNF-α	Rat, acute	100 μL, intramyocardial	Significant anti-inflammatory benefits and improved cardiac function	Somasuntharam et al., 2016
Organic-inorganic hybrid hollow mesoporous organosilica nanoparticles (HMONs)/20	Hepatocyte growth factor (HGF) gene-transfected BMMSCs	Rat, acute	2 × 106 HGF gene-transfected BMMSCs, intramyocardial	Decreased apoptotic cardiomyocytes, reduced infarct scar size, relieved interstitial fibrosis, increased angiogenesis, and improved cardiac functions	Zhu et al., 2016
Complex of recombinant baculovirus and Tat/DNA nanoparticles/500	Angiopoietin-1 gene	Rat, acute	300 μL, intramyocardial	Increased capillary density, reduced infarct size and improved cardiac functions	Paul et al., 2011