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. 2020 Jun 24;11:1172. doi: 10.3389/fmicb.2020.01172

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Copyright © 2020 Santajit, Seesuay, Mahasongkram, Sookrung, Pumirat, Ampawong, Reamtong, Chongsa-Nguan, Chaicumpa and Indrawattana.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The percentages of apoptotic HeLa cells exposed to different concentrations of 3O-C12-HSL. (A) Bar graph of average percentages (means ± SD) of apoptotic cells from three independent experiments after exposure to 10, 25, 50, 75, and 100 μM of C12-HSL, compared with the cells in medium alone. (B) The density plots of HeLa cells after treatment with 10, 25, 50, 75, and 100 μM of C12-HSL, and control cells stained by Annexin V-FITC/PI and subjected to flow cytometric analysis (representative of three independent experiments). The cytotoxic activity of the 3O-C12-HSL was dose-dependent. Q1, necrotic cells (Annexin V negative/PI positive); Q2, late apoptotic cells (Annexin V positive/PI positive); Q3, early-apoptotic cells (Annexin V positive/PI negative), and Q4, viable cells (Annexin V negative/PI negative).