Table 9.

Consensus on priorities for future research related to vaccines against respiratory syncytial virus and Group B Streptococcus diseases during pregnancy.

Group B Streptococcus vaccines

1. The epidemiology of GBS disease in early life and risk factors for GBS disease in diverse geographic settings

2. Ideal composition of GBS vaccines to achieve highest protection against early and late onset GBS disease

3. Correlate(s) of protection against early and late onset GBS disease

4. Whether GBS vaccines given to pregnant women interfere with vaccines given in infancy and conjugated to TT and DT as carrier proteins

5. Effectiveness of GBS vaccines administered during pregnancy in reduction of early and late onset GBS disease

Respiratory syncytial virus

1. Definition of ideal timing of vaccination in pregnancy to achieve highest immunogenicity in infants

2. Mathematical modeling to inform clinical trials design to better define infants who will benefit the most from vaccination during pregnancy

3. Correlate(s) of protection against RSV disease in infancy

4. Epidemiology of RSV disease in 1st and 2nd years of life in offspring of mothers vaccinated during pregnancy

GBS, Group B Streptococcus; TT, Tetanus toxoid; DT, Diphtheria toxoid; RSV, Respiratory Syncytial Virus.