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. 2020 Jun 24;13:101. doi: 10.3389/fnmol.2020.00101

FIGURE 1.

FIGURE 1

Characteristics of tau deposits in AGD. Hyper-phosphorylated tau deposits are seen in the CA1 region of the hippocampus (CA1: A), subiculum (subic: B,F,J,M,N), entorhinal cortex (EC: C), white matter of the hippocampus (WM: E,H,K), and periventricular region of the temporal horn (perventr: F,I,L). Grains are identified as small round, lobulated, or comma-shaped deposits in the neuropil (A–C,D,G,J). Grains are accompanied by pre-tangles in neurons (C,D,G,J), and, rarely, by neurons with dense granular inclusions (D). In addition, oligodendroglial deposits form coiled bodies and cytoplasmic inclusions around the nucleus (E,H,K). Thorn-shaped astrocytes (TSAs) are common in the periventricular white matter (F,I,L). All these deposits are stained with AT8 antibodies (A–F), PHF1 (G–I), and anti-P-tau Ser262 (J–L). Grains and pre-tangles are composed of 4Rtau (M,N) and do not contain 3Rtau (O). Paraffin sections, processed for immunohistochemistry, and slightly counterstained with hematoxylin; (A,B), bar = 55 μm; (D–O), bar = 30 μm.