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. 2020 Jun 30;10:10664. doi: 10.1038/s41598-020-65993-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The X-ray crystal structure of GRL-063 bound to the active site of wild-type HIV-1 protease (PR_WT). Carbon atoms of GRL-063 are shown in orange and subunits of PR_WT in green tones. Nitrogen, oxygen, sulfur, and fluorine atoms are shown in blue, red, yellow, and cyan, respectively. Hydrogen bond interactions that took place between GRL-063 and the protease residues are indicated by gray dashed lines, and two fluorine atoms are highlighted by cyan spheres.