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. 2020 Jun 30;10:10641. doi: 10.1038/s41598-020-67446-z

Figure 3.

Figure 3

Selected snoRNA expression in OA-like conditions. (A) SnoRNA expression following IL-1β treatment of non-OA HAC pool of n = 4 donors. Gene expression of SNORD116, SNORA26, SNORD96A, SNORD33, SNORD44, SNORD66, SNORD95, SNORD98 were was measured using qRT-PCR following treatment of non-OA HACs with IL-1β (10 ng/ml) for 24 h. (B) SnoRNA expression following treatment of non-OA HAC pool of n = 4 donors with 20% OA synovial fluid (SF) (derived from a pool of ten donors) for 24 h. Gene expression changes were measured using 2−ΔCT expression relative to miR6786. Data represents the mean + standard error mean, p values indicated as follows; *p < 0.05; **p < 0.01. Within the graphs black represents control and grey treatments.