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. 2020 Jun 30;10:10597. doi: 10.1038/s41598-020-67325-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptome analysis using next-generation sequencing in BEAS-2B and A549 cells treated with TGF-β for 72 h to screen EMT and stemness genes. (A) A distinct separation of mRNA expression patterns of cells treated with or without TGF-β was indicated by heat map of hierarchical clustering. (B) mRNA expression levels of N-cadherin, fibronectin, Vimentin, slug, and snail were increased in lung cells treated with TGF-β whereas those of E-cadherin were decreased in cells treated with TGF-β. (C) Expression levels of stem cell markers (CD44 and CD87) were enhanced following TGF-β treatment.