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. 2020 Jun 30;10:10597. doi: 10.1038/s41598-020-67325-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TGF-β induced slug and CD87 activations by their promoter DNA demethylations. (A) After treatment with either DNA methyltransferase inhibitor (AZA) or TGF-β, real-time RT-PCR indicated significantly enhanced slug and CD87 expressions compared with controls (non-AZA + non-TGF-β) in BEAS-2B and A549 cells. Data are presented as mean ± SE (n = 3, *P < 0.05). (B, C) Methylation-specific PCR revealed increased unmethylation levels of slug and CD87 genes in TGF-β treated cell groups whereas methylation levels of these genes were decreased following TGF-β treatment. These expression levels were compared with controls (non-TGF-β). Cropped images of Figs. B and C are displayed, uncropped blots are displayed in Supplementary Figs. S2 and S3. Data are presented as mean ± SE (n = 3, *P < 0.05).