Table 1.
Next-generation sequencing analysis for fold change and gene volume of EMT and stem cell marker expressions induced by TGF-β.
| Gene | Fold change | Gene volume | ||
|---|---|---|---|---|
| BEAS-2B | A549 | BEAS-2B | A549 | |
| EMT related | ||||
| E-cadherin | − 5.131572 | − 6.16003 | 3.836665 | 3.210531 |
| N-cadherin | 4.99275 | 3.846411 | 3.915075 | 3.275512 |
| Fibronectin | 5.995764 | 5.927276 | 5.498908 | 5.162317 |
| Vimentin | 2.87307 | 2.532724 | 8.781097 | 9.386723 |
| α-SMA | 1.968616 | 1.050212 | 1.570309 | 2.143424 |
| Slug | 2.130321 | 2.102772 | 0.381627 | 0.742718 |
| Snail | 2.603393 | 2.879873 | 2.868386 | 3.170173 |
| Twist1 | − 1.095069 | − 1.1355 | 1.340565 | 1.423161 |
| Twist2 | − 1.103786 | − 1.14108 | 2.368498 | 3.055397 |
| ZEB1 | 1.867336 | 1.335399 | 1.888146 | 2.674815 |
| ZEB2 | 1.128909 | 1.072538 | 0.460226 | 0.588725 |
| ZO-1 | 1.369319 | 1.524285 | 4.877554 | 5.275308 |
| Stem cell related | ||||
| CD44 | 1.846255 | 1.998812 | 6.509078 | 7.17178 |
| CXCR4 | 1.051758 | − 1.13452 | 0.476323 | 0.121663 |
| ABCG2 | − 4.241183 | − 2.25365 | 1.812526 | 1.415971 |
| ALDH1A1 | 1.132919 | 1.393279 | 11.74794 | 11.41651 |
| EpCAM | − 3.548091 | − 2.12584 | 4.650325 | 1.94072 |
| CD90 | 1.379704 | 1.9047 | 0.522715 | 1.466032 |
| Nanog | 1.184785 | − 1.01217 | 0.112677 | 0.009034 |
| SOX2 | − 2.840429 | − 1.42603 | 0.703701 | 0.328854 |
| SSEA4 | 1.039819 | − 1.2167 | 1.810111 | 2.276493 |
| CD166 | 1.06801 | 1.618312 | 5.318266 | 5.592176 |
| BMI-1 | 1.025095 | 1.377714 | 3.322621 | 2.855195 |
| Nestin | − 1.01858 | − 1.21427 | 1.13823 | 1.034249 |
| Musashi-1 | 1.122545 | 1.180573 | 1.117478 | 0.757083 |
| CD87 | 1.906373 | 2.066904 | 6.315332 | 5.832158 |
| MET | 1.155958 | − 1.08475 | 5.463949 | 4.968498 |
| SLC3A2 | − 1.563981 | − 1.08387 | 8.266959 | 8.284722 |
| c-Myc | 1.057811 | − 1.04973 | 6.020233 | 5.450993 |
| KLF4 | − 2.110727 | − 1.71194 | 2.649128 | 2.578687 |