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. 2020 Jun 24;10:906. doi: 10.3389/fonc.2020.00906

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Copyright © 2020 Zhao, Li, Li, Xu, Yang, Shi, Zhang and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression of hsa_circRPPH1_015 was associated with the progression of BC. (A) Hsa_circRPPH1_015 expression in BC tissues and adjacent normal tissues determined by RT-qPCR. (B) The correlation analysis between hsa_circRPPH1_015 expression and prognosis of patients with BC by Kaplan–Meier survival analysis. (C) The expression of hsa_circRPPH1_015 in normal breast cell lines and BC cell lines determined by TaqMan-PCR assay. (D) Corelation analysis of prognosis and survival in patients with high and low expression of miR-326 by Kaplan–Meier survival analysis. (E) Corelation analysis of prognosis and survival in patients with high and low expression of ELK1 by Kaplan–Meier survival analysis. *p < 0.05 vs. the adjacent normal tissues or HBL-100 cell line. The quantitative analysis results were measurement data and compared by paired t-test between two groups and by one-way ANOVA among multiple groups. Values were obtained from three independent experiments. BC, breast cancer; ELK1, ETS-domain containing protein; RT-qPCR, reverse transcription quantitative polymerase chain reaction; ANOVA, analysis of variance.