TABLE 1.
In vitro 1 week | In vitro 2 weeks | In vitro 3 weeks | In vivo 3 months | In vivo 12 months | Control human cornea | Control rabbit cornea | ||
CK3/12 | HOC | + | + | ++ | +++ | +++ | +++ | +++ |
HHC | − | − | ++ | +++ | +++ | |||
PKG | HOC | + | + | +++ | +++ | +++ | +++ | ± |
HHC | − | ++ | ++ | +++ | +++ | |||
CRY-αA | HOC | + | ++ | +++ | +++ | +++ | +++ | +++ |
HHC | + | + | +++ | +++ | +++ | |||
CRY-αB | HOC | − | ± | + | ± | ++ | +++ | +++ |
HHC | ± | + | + | + | +++ | |||
CRY-β | HOC | + | + | ++ | ++ | ++ | ++ | ++ |
HHC | − | + | + | ++ | + | |||
CRY-λ1 | HOC | ++ | ++ | ++ | + | + | +++ | ± |
HHC | ++ | ++ | ++ | + | ++ | |||
CRY-Z | HOC | − | + | ++ | ++ | ++ | +++ | + |
HHC | + | ++ | +++ | ++ | +++ |
HOC, human orthotypical cornea; HHC, human heterotypical cornea.