TABLE 1.

Multiple reaction monitoring transitions and retention times of wt‐Aβ40 and ‐Aβ40 variants analyzed in the APP heterozygosity experiments

Variant	Name	Mass (Da)	Retention time (min)	Precursor ion (m/z)	Product ions (m/z)
	Wild‐type	4329.9	4.06	1083.0	1054.1, 1029.1,1000.8
L34V	Piedmont	4315.8	3.93	1079.9	1050.5, 1011.5, 997.4
A21G	Flemish	4315.8	3.97	1079.9	1050.5, 1011.5, 997.4
H6R	English	4348.9	4.12	1088.2	1058.9, 1033.9, 1005.4
D7N	Tottori	4328.9	4.14	1083.0	1054.1, 1029.1, 1000.8
E22G	Arctic	4257.8	4.18	1065.5	1036.2, 1011.5, 997.1
E22∆	Osaka	4200.8	4.22	1051.2	943.9, 914.8, 882.7
E22Q	Dutch	4328.9	4.24	1083.0	1054.1, 1029.1, 1000.8
D23N	Iowa	4328.9	4.32	1083.0	1054.1, 1029.1, 1000.8
E22K	Italian	4328.9	4.42	1083.0	1054.1, 1029.1, 1000.8

Abbreviations: Aβ, amyloid beta; APP, amyloid‐precursor protein; multiple reaction monitoring; m/z, mass‐to‐charge ratio; wt, wild type