TABLE 3.
Prevalence of OI in UC and CD Compared With Non-IBD Controls
| CD | UC | Non-IBD | Prevalence in CDa | Prevalence in UCa | Prevalence in Non-IBDa | PR in CD vs Non-IBD | PR in UC vs Non-IBD | PR in CD vs UC | |
|---|---|---|---|---|---|---|---|---|---|
| Histoplasmosis | 160 | 120 | 8030 | 104.4 | 93.4 | 22.9 | 4.57; 95% CI, 3.91–5.34; P < 0.0001 | 4.09; 95% CI, 3.41–4.89; P < 0.0001 | 1.12; 95% CI, 0.88–1.42; P = 0.387 |
| Cryptococcosis | 40 | 20 | 1410 | 26.1 | 15.6 | 4.0 | 6.50; 95% CI, 4.75–8.90; P < 0.0001 | 3.88; 95% CI, 2.49–6.03; P < 0.0001 | 1.68; 95% CI, 0.98–2.87; P = 0.073 |
| Pneumocystis | 60 | 50 | 3310 | 39.1 | 38.9 | 9.4 | 4.16; 95% CI, 3.22–5.36; P < 0.0001 | 4.13; 95% CI, 3.12–5.46; P < 0.0001 | 1.01; 95% CI, 0.69–1.46; P > 0.999 |
| Aspergillosis | 110 | 110 | 5820 | 71.8 | 85.6 | 16.6 | 4.33; 95% CI, 3.59–5.23; P < 0.0001 | 5.17; 95% CI, 4.28–6.24; P < 0.0001 | 0.84; 95% CI, 0.64–1.09; P = 0.215 |
| Candidiasis | 8980 | 7330 | 701,000 | 5858.2 | 5702.5 | 1995.0 | 2.94; 95% CI, 2.88–3.00; P < 0.0001 | 2.86; 95% CI, 2.80–2.92; P < 0.0001 | 1.03; 95% CI, 1.00–1.06; P = 0.078 |
| Listeriosis | 10 | 10 | 300 | 6.5 | 7.8 | 0.9 | 7.64; 95% CI, 4.07–14.35; P < 0.0001 | 9.11; 95% CI, 4.85–17.11; P < 0.0001 | 0.84; 95% CI, 0.35–2.01; P = 0.861 |
| Legionella | 30 | 40 | 4000 | 19.6 | 31.1 | 11.4 | 1.72; 95% CI, 1.20–2.46; P = 0.008 | 2.73; 95% CI, 2.00–3.73; P < 0.0001 | 0.63; 95% CI, 0.39–1.01; P = 0.070 |
| Pneumococcal disease | 450 | 390 | 31,310 | 293.6 | 303.4 | 89.1 | 3.30; 95% CI, 3.00–3.62; P < 0.0001 | 3.41; 95% CI, 3.08–3.76; P < 0.0001 | 0.97; 95% CI, 0.85–1.11; P = 0.657 |
| Nocardiosis | 10 | 10 | 630 | 6.5 | 7.8 | 1.8 | 3.64; 95% CI, 1.95–6.80; P = 0.0001 | 4.34; 95% CI, 2.32–8.10; P = 0.0003 | 0.84; 95% CI, 0.35–2.01; P = 0.861 |
| Clostridium difficile | 3980 | 5020 | 79,580 | 2596.4 | 3905.4 | 226.5 | 11.46; 95% CI, 11.11–11.83; P < 0.0001 | 17.24; 95% CI, 16.77–17.73; P < 0.0001 | 0.66; 95% CI, 0.64–0.69; P < 0.0001 |
| Tuberculosis | 240 | 160 | 10,370 | 156.6 | 124.5 | 29.5 | 5.31; 95% CI, 4.67–6.03; P < 0.0001 | 4.22; 95% CI, 3.61–4.93; P < 0.0001 | 1.26; 95% CI, 1.03–1.54; P = 0.0270 |
| Influenza | 3560 | 3010 | 515,960 | 2322.4 | 2341.7 | 1468.4 | 1.55; 95% CI, 1.50–1.60; P < 0.0001 | 1.60; 95% CI, 1.54–1.65; P < 0.0001 | 0.99; 95% CI, 0.95–1.04; P = 0.735 |
| HPV | 5980 | 5260 | 691,020 | 3901.1 | 4092.1 | 1966.6 | 1.98; 95% CI, 1.94–2.03; P < 0.0001 | 2.08; 95% CI, 2.03–2.14; P < 0.0001 | 0.95; 95% CI, 0.92–0.99; P = 0.010 |
| EBV | 370 | 290 | 46,360 | 241.4 | 225.6 | 131.9 | 1.83; 95% CI, 1.65–2.03; P < 0.0001 | 1.71; 95% CI, 1.52–1.92; P < 0.0001 | 1.07; 95% CI, 0.92–1.25; P = 0.411 |
| CMV | 350 | 410 | 7690 | 228.3 | 319.0 | 21.9 | 10.43; 95% CI, 9.37–11.61; P < 0.0001 | 14.57; 95% CI, 13.20–16.09; P < 0.001 | 0.72; 95% CI, 0.62–0.83; P < 0.0001 |
| HSV | 2970 | 2460 | 358,220 | 1937.5 | 1913.8 | 1019.5 | 1.90; 95% CI, 1.83–1.97; P < 0.0001 | 1.88; 95% CI, 1.81–1.95; P < 0.0001 | 1.01; 95% CI, 0.96–1.07; P = 0.648 |
aPrevalence reported per 100,000.