TABLE 4.
Prevalence of OI by Age Group in CD and UC as Compared With Non-IBD Controls
| 4a. Crohn’s Disease | ||||||||
|---|---|---|---|---|---|---|---|---|
| Children, No. | Adults, No. | Elderly, No. | Prevalence, Childrena | Prevalence, Adultsa | Prevalence, Elderlya | PR in Children vs Adults | PR in Elderly vs Adults | |
| Histoplasmosis | N/A | 110 | 60 | N/A | 98.0 | 156.4 | N/A | 1.60; 95% CI, 1.17–2.19; P = 0.006 |
| Cryptococcosis | 0 | 20 | 20 | 0.0 | 17.8 | 52.1 | 1.04; 95% CI, 0.06–17.19; P = 0.772 | 2.93; 95% CI, 1.57–5.44; P = 0.001 |
| Pneumocystis | N/A | 40 | 20 | N/A | 35.6 | 52.1 | N/A | 1.46; 95% CI, 0.86–2.50; P = 0.216 |
| Aspergillosis | 0 | 50 | 50 | 0.0 | 44.5 | 130.3 | 0.42; 95% CI, 0.03–6.74; P > 0.999 | 2.93; 95% CI, 1.98–4.33; P < 0.0001 |
| Candidiasis | 90 | 6200 | 2690 | 3333.3 | 5523.9 | 7010.7 | 0.60; 95% CI, 0.49–0.74; P < 0.0001 | 1.27; 95% CI, 1.22–1.33; P < 0.0001 |
| C. difficile | 80 | 2630 | 1270 | 2963.0 | 2343.2 | 3309.9 | 1.26; 95% CI, 1.02–1.57; P = 0.048 | 1.41; 95% CI, 1.32–1.51; P < 0.0001 |
| Influenza | 150 | 2520 | 890 | 5555.6 | 2245.2 | 2319.5 | 2.47; 95% CI, 2.11–2.90; P < 0.0001 | 1.03; 95% CI, 0.96–1.11; P = 0.398 |
| HPV | 150 | 4810 | 1010 | 5555.6 | 4285.5 | 2632.3 | 1.30; 95% CI, 1.11–1.52; P = 0.002 | 0.61; 95% CI, 0.57–0.66; P < 0.0001 |
| EBV | 20 | 310 | 40 | 740.7 | 276.2 | 104.2 | 2.68; 95% CI, 1.71–4.21; P = 0.0003 | 0.38; 95% CI, 0.27–0.52; P < 0.0001 |
| CMV | N/A | 260 | 90 | N/A | 231.6 | 234.6 | N/A | 1.01; 95% CI, 0.80–1.29; P = 0.960 |
| HSV | 70 | 2350 | 550 | 2592.6 | 2093.7 | 1433.4 | 1.24; 95% CI, 0.98–1.57; P = 0.093 | 0.68; 95% CI, 0.62–0.75; P < 0.0001 |
| Pneumococcal disease | N/A | 210 | 240 | N/A | 187.1 | 625.5 | N/A | 3.34; 95% CI, 2.78–4.02; P < 0.0001 |
| Tuberculosis | N/A | 170 | 70 | N/A | 195.8 | 172.5 | N/A | 1.20; 95% CI, 0.91–1.59; P = 0.218 |
| 4b. Ulcerative Colitis | ||||||||
| Children, No. | Adults, No. | Elderly, No. | Prevalence, Childrena | Prevalence, Adultsa | Prevalence, Elderlya | PR in Children vs Adults | PR in Elderly vs Adults | |
| Histoplasmosis | N/A | 60 | 60 | N/A | 69.1 | 147.9 | N/A | 2.14; 95% CI, 1.50–3.06; P < 0.0001 |
| Cryptococcosis | 0 | 10 | N/A | 0.0 | 11.5 | N/A | 3.50; 95% CI, 0.20–59.88; P = 0.277 | N/A |
| Pneumocystis | N/A | 40 | 20 | 0.0 | 46.1 | 49.3 | N/A | 1.07; 95% CI, 0.63–1.83; P = 0.902 |
| Aspergillosis | 0 | 40 | 60 | 0.0 | 46.1 | 147.9 | 0.88; 95% CI, 0.05–14.22; P = 0.874 | 3.21; 95% CI, 2.15–4.79; P < 0.0001 |
| 4b. Ulcerative Colitis | ||||||||
| Children, No. | Adults, No. | Elderly, No. | Prevalence, Childrena | Prevalence, Adultsa | Prevalence, Elderlya | PR in Children vs Adults | PR in Elderly vs Adults | |
| Candidiasis | 60 | 4590 | 2690 | 4838.7 | 5287.4 | 6628.9 | 0.92; 95% CI, 0.71–1.17; P = 0.531 | 1.25; 95% CI, 1.20–1.31; P < 0.0001 |
| C. difficile | 70 | 2760 | 2190 | 5645.2 | 3179.4 | 5396.7 | 1.78; 95% CI, 1.41–2.24; P < 0.0001 | 1.70; 95% CI, 1.61–1.79; P < 0.0001 |
| Influenza | 50 | 2040 | 920 | 4032.3 | 2350.0 | 2267.1 | 1.72; 95% CI, 1.30–2.24; P = 0.0005 | 0.96; 95% CI, 0.89–1.04; P = 0.361 |
| HPV | 60 | 4190 | 1020 | 4838.7 | 4826.6 | 2513.6 | 1.00; 95% CI, 0.78–1.29; P > 0.999 | 0.52; 95% CI, 0.49–0.56; P < 0.0001 |
| EBV | 10 | 250 | 40 | 806.5 | 288.0 | 98.6 | 2.80; 95% CI, 1.49–5.26; P = 0.008 | 0.34; 95% CI, 0.25–0.48; P < 0.0001 |
| CMV | N/A | 290 | 120 | N/A | 334.1 | 295.7 | N/A | 0.89; 95% CI, 0.72–1.10; P = 0.283 |
| HSV | 20 | 1890 | 560 | 1612.9 | 2177.2 | 1380.0 | 0.74; 95% CI, 0.48–1.15; P = 0.201 | 0.63; 95% CI, 0.58–0.70; P < 0.0001 |
| Pneumococcal disease | N/A | 160 | 230 | N/A | 184.3 | 566.8 | N/A | 3.08; 95% CI, 2.51–3.76; P < 0.0001 |
| Tuberculosis | 0 | 100 | 60 | N/A | 115.2 | 147.9 | 0.35; 95% CI, 0.02–5.63; P > 0.999 | 1.28; 95% CI, 0.93–1.77; P = 0.150 |
aPrevalence reported per 100,000.