Table 2.

WHO Requirements for HCS Trials ²⁴

• Strong scientific justification.

• The potential benefits outweigh the risks.

• Researchers must consult and closely coordinate with the public, experts, funders, regulators, and policy makers.

• The studies are conducted at sites that can maintain the highest scientific, clinical, and ethical standards.

• Participant selection criteria limit and minimize risk.

• Studies are reviewed by specialized independent committees.

• Studies must use rigorous informed consent.