FIG 5.

Dysplasia and gastric cancer in response to Cag T4SS activity. Gerbils were infected with H. pylori VM202-203 and fed various diets as described in the legend to Fig. 4. (A) Frequency of dysplasia and/or cancer in uninfected and infected animals receiving chow containing the indicated concentrations of doxycycline at various time points. Significance was calculated using Fisher’s exact test with Benjamini-Hochberg multitest comparison method (with a false discovery rate of 5%). *. P < 0.0015. (B and C) Representative gastric antral histology in infected animals, showing dysplastic glands (black arrows) and invasive carcinoma penetrating the muscularis mucosa and submucosa (white arrow). Magnification, 100×.