TABLE 1.
Evaluated HBV DNA Tests
| HBV‐DNA Test (Abbreviation) | Cobas HPS | Cobas HBV | Cobas HBV+RT | Aptima HBV | Xpert HBV |
|---|---|---|---|---|---|
| Full description | Real‐time PCR COBAS TaqMan HBV test for use with the HPS | Real‐time PCR cobas HBV DNA assay for use on the cobas 6800/8800 systems | Real‐time PCR cobas HBV DNA assay for use on the cobas 6800/8800 systems, including a nonstandard total nucleic acid software | TMA Aptima HBV Quant assay for use with the Hologic Panther system | Xpert HBV Viral load |
| Method of amplification | Real‐time PCR | Real‐time PCR | Real‐time PCR | TMA | Real‐time PCR |
| Significant RT capability | No | No | Yes | Yes | No |
| Limit of detection* (IU/mL) | 5.9 | 2.7 | n.d. | 5.58 | 10 |
| LLOQ* (IU/mL) | 29 | 10 | 10 | 5.58 | 10 |
*
In plasma.
Abbreviation: n.d., not determined.