Table 1.
Demographics and standard hemodynamics
| Pediatric |
Adult |
|||
|---|---|---|---|---|
| PAH | Control | PAH | Control | |
| Age, yr | 13.8 ± 3.2++ | 12.1 ± 4.3++ | 62.7 ± 8.8 | 57.7 ± 9.2 |
| BSA, m2 | 1.26 ± 0.34++ | 1.15 ± 0.21++ | 1.74 ± 0.31 | 1.87 ± 0.25 |
| Sex (%female) | 7 (70) | 6 (60) | 4 (40) | 5 (50) |
| mPAP, mmHg | 45 ± 17 | 38 ± 11 | ||
| PVRi, WU/m2 | 9.7 (6.1–11.3) | 8.4 (5.4–10.6) | ||
| TAPSE, cm | 2.4 ± 0.4 | 2.0 ± 0.6 | ||
| BNP, ng/l | 14 (14–17) | 23 (8–64) | ||
| RV EDVi, ml/m2 | 106 ± 19** | 79 ± 11 | 90 ± 23* | 70 ± 13 |
| RV ESVi, ml/m2 | 51 ± 15** | 33 ± 15 | 52 ± 17* | 37 ± 13 |
| RV SVi, ml/m2 | 55 ± 10*+ | 46 ± 10+ | 38 ± 13 | 35 ± 5 |
| RV EF, % | 52 ± 8*+ | 58 ± 4++ | 42 ± 12 | 49 ± 6 |
| RV CI, l·min−1·m2 | 4.1 ± 1.2+ | 3.6 ± 0.2++ | 2.9 ± 1.0* | 2.0 ± 0.3 |
Values are means ± SD; n = 10. BNP, brain natriuretic peptide; BSA, CI, cardiac index; EDVi, end-diastolic volume index; EF, ejection fraction; ESVi, end-systolic volume index; mPAP, mean pulmonary arterial pressure; PAH, pulmonary arterial hypertension; PVRi, pulmonary vascular resistance index; RV, right ventricle; SVi, stroke volume index; TAPSE, trans-annular plane systolic excursion.
*
P < 0.05 and
**
P < 0.01 from respective control;
+
P < 0.05 and
++
P < 0.01 from respective PAH or control group.