Table 1.
DBP induced alterations in oxidative stress parameters in the liver tissue of rats studied up to three-generations.
| Groups | LPO (μmoles of MDA/g wet wt. tissue) | SOD (U/mg protein) | CAT (μmoles H2O2 hydrolyzed/ min/mg protein) | GPx (μmoles of NADPH oxidized/min/mg protein) | GSH (μmoles/ min/g wet wt. tissue) | |
|---|---|---|---|---|---|---|
| F1 | C | 1.29 ± 0.17 | 2.37 ± 0.61 | 1.36 ± 0.43 | 0.27 ± 0.05 | 4.17 ± 0.38 |
| E | 1.30 ± 0.20a,ns (+0.78) | 1.60 ± 1.35a,ns (-32.49) | 0.58 ± 0.16a,ns (-57.35) | 0.26 ± 0.06a,ns (-3.70) | 2.45 ± 0.19b,ns (-41.25) | |
| F2 | C | 1.15 ± 0.11 | 2.64 ± 0.36 | 1.19 ± 0.46 | 0.21 ± 0.02 | 4.34 ± 0.38 |
| E | 1.40 ± 0.09a,ns (+21.74) | 1.15 ± 0.32a,ns (-56.44) | 0.81 ± 0.38a,ns (-31.93) | 0.34 ± 0.05a,ns (+61.90) | 2.06 ± 0.15b,ns (-52.53) | |
| F3 | C | 1.35 ± 0.12 | 1.90 ± 0.19 | 1.25 ± 0.45 | 0.22 ± 0.01 | 4.15 ± 0.39 |
| E | 1.48 ± 0.10a,ns (+9.63) | 1.43 ± 0.41a,ns (-24.74) | 0.31 ± 0.11a,ns (-75.20) | 0.11 ± 0.03a,ns (-50.00) | 0.68 ± 0.08a,ns (-83.61) |
Values are mean ± SE of six observations.
Symbol ‘*’ significantly different and ‘ns’ non-significant from their corresponding control as determined by Student’s t-test, P < 0.05; alphabets ‘a’ and ‘b’ are significantly different among experimental groups in the inter-generational analysis as determined by one-way ANOVA followed by post-hoc Tukey’s HSD test, P < 0.05. F1, F2 and F3 represent first, second and third generation respectively. C- Control, E- Experimental.