Table 1. Characteristics of donors and recipients (including post-operative treatment and outcomes).
| Characteristic | Case 1 | Control 1 | Case 2 | Control 2 | Case 3 | Control 3 | Case 4 | Control 4 | Case 5 | Control 5 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age, y | 41 | 34 | 59 | 33 | 49 | 11 | 38 | 5 | 64 | 55 | |||
| Sex | F | F | F | F | F | M | M | M | F | F | |||
| BMI, kg/m2 | 22.1 | 24.8 | 25.0 | 18.4 | 20.8 | 15.6 | 19.7 | 14.0 | 20.5 | 15.8 | |||
| Primary kidney disease | Polycystic kidney | CGN | CGN | CGN | CGN | Polycystic kidney | CGN | ICGN | CGN | CGN | |||
| History of hypertension, y | 3 | 6 | 10 | No | 7 | No | 8 | 1 | 2 | 4 | |||
| History of diabetes | No | No | No | No | No | No | No | No | No | No | |||
| Dialysis modality | HD | PD + HD | HD | HD | PD | PD | HD | HD | HD | HD | |||
| Duration of dialysis, y | 10 | 6 | 2.5 | 9 | 10.5 | 1 | 8 | 1 | 4 | 4 | |||
| Duration of preoperative hypotension, y | 7 | N/A | 2 | N/A | 5.5 | N/A | 1 | N/A | 3.5 | N/A | |||
| Hypotensive symptom | Fatigue | N/A | Fatigue | N/A | Fatigue | N/A | Dizzy, sweaty | N/A | Dizzy, sweaty, fatigue | N/A | |||
| Intra-dialytic BP, mmHg | 80/50 | 135/85 | 70/40 | 125/80 | 90/60 | 105/60 | 70/50 | 110/80 | 90/50 | 140/75 | |||
| Inter-dialytic BP, mmHg | 90/60 | 155/95 | 85/45 | 130/85 | 95/60 | 110/70 | 80/60 | 130/85 | 90/50 | 145/75 | |||
| HLA mismatching, n | 4 | 0 | 2 | 4 | 3 | 3 | 4 | 6 | 0 | 0 | |||
| PRA-I | Negative | ||||||||||||
| PRA-II | Negative | ||||||||||||
| CIT, h | 8 | 8 | 19 | 19 | 6 | 11 | 10 | 10 | 8 | 8 | |||
| WIT, min | 0 | 0 | 16 | 16 | 14 | 20 | 14 | 14 | 10 | 10 | |||
| Donor | |||||||||||||
| Donor age, month | 51 | 28 | 11 | 11 | 34 | ||||||||
| Donor sex | M | M | F | F | F | ||||||||
| Donor weight, kg | 20 | 15 | 12 | 13 | 13 | ||||||||
| Cause of donor death | Drowning with aspiration pneumonitis | High falling injury with skull fracture | Craniocerebral trauma by accident | Craniocerebral trauma by accident | Craniocerebral trauma by accident | ||||||||
| Donor SCr at transplantation, ìmol/L | 44 | 312 | 19 | 45 | 26 | ||||||||
| Treatment | |||||||||||||
| Introduction therapy | Basiliximab | ATG | ATG | ATG | ATG | ||||||||
| Immunosuppression | TAC + MMF + GS | ||||||||||||
| Pressor therapy | Dopamine, aramine | N/A | Dopamine, aramine | N/A | No | N/A | Dopamine, aramine, norepinephrine | N/A | Dopamine | N/A | |||
| Outcome | |||||||||||||
| DGF | Yes | No | No | No | Yes | Yes | No | No | No | No | |||
| BP at 12 months after transplantation, mmHg | 110/70 | 135/85 | 120/85 | 110/70 | 125/85 | 125/75 | 115/85 | 115/75 | 125/75 | 110/70 | |||
| SCr at 12 months after transplantation, ìmol/L | 63 | 65 | 66 | 72 | 108 | 82 | 84 | 41 | 69 | 63 | |||
| Graft loss | No | No | No | No | No | No | No | No | No | No | |||
| Death | No | No | No | No | No | No | No | No | No | No | |||
ATG, anti-thymocyte globulin; BMI, body mass index; BP, blood pressure; CGN, chronic glomerulonephritis; CIT, cold ischemia time; DGF, delayed graft function; GS, glucocorticoids; HD, hemodialysis; HLA, human leukocyte antigen; ICGN, immune complex-mediated glomerulonephritis; MMF, mycophenolate mofetil; N/A, not applicable; PD, peritoneal dialysis; PRA, panel reactive antibodies; SCr, serum creatinine; TAC, tacrolimus; WIT, warm ischemia time.