Table 1.

A table of databases that used a form of manual curation to populate entries. Reported number of entities and relationships are relative to the time of publication.

Database [Reference]	Short Description	Number of Entries	Entity Types	Relationship Types	Method of Population
BioGrid [52]	A database for major model organisms. It contains genetic and proteomic information.	572,084	Genes, Proteins	Protein-Protein interactions	Semi-automatic methods
Comparative Toxicogenomics Database [53]	A database that contains manually curated chemical-gene-disease interactions and relationships.	2,429,689	Chemicals (Drugs), Genes, Diseases	Drug-Genes, Drug-Disease, Disease-Gene mappings	Manual curation and Automated systems
Comprehensive Antibiotic Resistance Database [54]	Manually curated database that contains information about the molecular basis of antimicrobial resistance.	174,443	Drugs, Genes, Variants	Drug-Gene, Drug-Variant mappings	Manual curation
COSMIC [30]	A database that contains high resolution human cancer genetic information.	35,946,704	Genes, Variants, Tumor Types	Gene-Variant Mappings	Manual Curation
Entrez-Gene [55]	NCBI’s Gene annotation database that contains information pertaining to genes, gene’s organism source, phenotypes etc.	7,883,114	Genes, Species and Phenotypes	Gene-Phenotypes and Genes-Species mappings	Semi-automated curation
OMIM [56]	A database that contains phenotype and genotype information	25,153	Genes, Phenotypes	Gene-Phenotype mappings	Manual Curation
PharmGKB [57]	A database that contains genetic, phenotypic, and clinical information related to pharmacogenomic studies.	43,112	Drugs, Genes, Phenotypes, Variants, Pathways	Gene-Phenotypes, Pathway-Drugs, Gene-Variants, Gene-Pathways	Manual Curation and Automated Methods
UniProt [58]	A protein–protein interaction database that contains proteomic information.	560,823	Proteins, Protein sequences	Protein-Protein interactions	Manual and Automated Curation