Fig. 2.

Overlap of significantly regulated genes between culture systems and breast cancer cell lines. (A) Venn diagram illustrating the number of significantly regulated genes between cells cultured in patient-derived scaffolds (PDS) or xenograft compared to 2D using breast cancer cell lines MCF7 and MDA-MB-231, as well as overlap between the systems. (B) Enriched Reactome pathways associated with the 372 genes commonly regulated between PDS and 2D, as well as between xenograft and 2D, in both cell lines. Dashed line indicates q = 0.05.