Table 1.
Description of the study sample.
| N = 8810a | %b/Median [IQR] | % of missing valuesc | |
|---|---|---|---|
| Outcomes (44/45 years) | |||
| C-reactive protein (mg/L), median [IQR] | 0.9 [0.5, 2.1] | ||
| Fibrinogen (g/L), median [IQR] | 2.9 [2.6, 3.2] | ||
| von Willebrand factor (IU, dl), median[IQR] | 119 [98, 140] | ||
| Prospective childhood adversities (0–16 years) | |||
| Parental separation/divorce | 5.2 | 37.3 | |
| Parental substance misuse | 0.6 | 33.5 | |
| Parental death | 2.6 | 36.4 | |
| Parental mental illness | 4.3 | 26.4 | |
| Physical neglect | 4.4 | 17.1 | |
| Parental offending | 4.6 | 45.4 | |
| Family conflict | 3.6 | 33.5 | |
| Prospective ACE score | |||
| 0 ACEs | 82.2 | d | |
| 1 ACE | 12.9 | ||
| 2 + ACEs | 5.0 | ||
| Retrospective childhood adversities (33/44/45 years) | |||
| Parental separation/divorce | 7.5 | 22.1 | |
| Parental substance misuse | 13.5 | 0 | |
| Parental mental illness | 25.9 | 0 | |
| Family conflict | 13.0 | 0 | |
| Emotional neglect | 11.4 | 0 | |
| Physical abuse | 5.9 | 0 | |
| Sexual abuse | 1.3 | 0 | |
| Psychological abuse | 9.6 | 0 | |
| Witnessed abuse | 5.7 | 0 | |
| Retrospective ACE score | |||
| 0 ACEs | 60.3 | d | |
| 1 ACE | 16.2 | ||
| 2 ACEs | 10.3 | ||
| 3 ACEs | 5.0 | ||
| 4 + ACEs | 8.3 | ||
| Covariates | |||
| Gender, % female | 50.3 | 0 | |
| Father's social class (birth) | 12.7 | ||
| I professional | 5.1 | ||
| II managerial & technical | 14.5 | ||
| IIINM skilled non-manual | 10.3 | ||
| IIIM skilled manual | 50.4 | ||
| IV semi-skilled manual | 11.8 | ||
| V unskilled manual | 7.9 | ||
| Birthweight (grams), mean (SD) | 3342.3 (512.0) | 11.9 | |
| Maternal age at birth (years), mean (SD) | 27.5 (5.6) | 8.2 | |
| Breastfeeding (reported at 7 years) | 17.1 | ||
| No | 29.3 | ||
| Up to 1 month | 24.3 | ||
| Longer than 1 month | 46.5 | ||
| Mother's education (birth) | 8.5 | ||
| Stayed beyond min leaving age | 27.5 | ||
| Left before min leaving age | 72.5 | ||
| Gestational age (days), mean (SD) | 281.0 (11.8) | 19.1 | |
a
Analytic sample is comprised of those with complete information on relevant ACEs in the retrospective ACEs questionnaire at age 44/45 and at least one observed inflammatory marker;
b
Pooled percentages are shown as data are imputed and the specific Ns therefore vary across the 20 imputed datasets.
c
Missing values reported for those who had complete information on retrospective ACEs questionnaire at age 44/45 and at least one observed inflammatory marker.
d
ACE scores were computed post-imputation and therefore have no missing data. Abbreviations: ACE = adverse childhood experience; IQR = interquartile range; SD = standard deviation