Table 1.

Summary of Significant Findings.

The following table summarises the findings of variability and mean differences meta-analyses of inflammatory markers in depression concordant between the main and sensitivity analyses.

marker	Meta-analysis of mean differences in immune parameters in depression compared with healthy controls	Meta-analysis of variability: CVR
CRP	↑ in patients g = 0.71; 95%CI: 0.50–0.92	↓ variability in patients CVR = 0.85; 95%CI: 0.75–0.98
IL-3	↑ in patients g = 0.60; 95%CI: 0.31–0.89	↔ CVR = 0.76; 95%CI: 0.56–1.04
IL-6	↑ in patients g = 0.61; 95%CI: 0.39–0.82	↔ CVR = 0.92; 95%CI: 0.81–1.05
IL-12	↑ in patients g = 1.18; 95%CI: 0.74–1.62	↓ variability in patients CVR = 0.61; 95%CI: 0.46–0.80
IL-18	↑ in patients g = 1.97; 95%CI: 1.00–2.95	↔ CVR = 0.86; 95%CI: 0.67–1.09
sIL-1RA	↑ in patients g = 0.53; 95%CI: 0.18–0.89	↔ CVR = 1.00; 95%CI: 0.84–1.20
sIL-2R	↑ in patients g = 0.71; 95%CI: 0.44–0.98	↓ variability in patients CVR = 0.85; 95%CI: 0.73–0.99
TNF α	↑ in patients g = 0.54; 95%CI: 0.32–0.76	↔ CVR = 0.96; 95%CI: 0.84–1.10