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. 2020 Jun 24;11:955. doi: 10.3389/fphar.2020.00955

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Copyright © 2020 Lin, Shao, Huang, Wen, Wang, Wen and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alterations in gut microbiota caused by Simiao decoction in the treatment of gouty arthritis mice. Effects of Simiao decoction on Chao1 (A) and Shannon (B) indices. PCoA score plots of gut microbiota based on UniFrac distance matrices (C). The abundances of 30 altered genera are shown as heatmaps (D). Spearman's correlations between 30 altered genera and gut inflammatory cytokines are shown as heatmaps (E). “+” represents p < 0.05 in the comparison with control group; “+ +” represents p < 0.01 in the comparison with control group; “#” represents p < 0.05 in the comparison with model group; “# #” represents p < 0.01 in the comparison with model group; “*” represents the Spearman rho value <0.05; and “**” the Spearman rho value p < 0.01. N = 7/group.