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. 2020 Jun 20;2020:9243681. doi: 10.1155/2020/9243681

Figure 1.

Figure 1

Glucose metabolism was upregulated in cisplatin-resistant A549/DDP cells. (a) Detection of cisplatin inhibition in cisplatin-sensitive or cisplatin-resistant A549 cells and A549/DDP cells. (b) Glucose consumption and (c) lactate production were measured in cisplatin-sensitive or cisplatin-resistant A549 cells and A549/DDP cells. Expression of glucose metabolism enzymes at the protein level or the mRNA level in cisplatin-sensitive or cisplatin-resistant A549 and A549/DDP cells by (d) western blot and (e) RT-PCR analysis. The results are presented as mean ± S.D. (n = 3); the experimental results are presented in triplicate. HK1, hexokinase 1; HK2, hexokinase 2; PFKP, platelet-type phosphofructokinase; PKM1/2, Pyruvate Kinase M1/2; PKM2, pyruvate kinase M2; GLUT1, glucose transporter 1; PDH, pyruvate dehydrogenase; LDHA, lactate dehydrogenase A.