Skip to main content
. 2020 Jun 20;2020:9243681. doi: 10.1155/2020/9243681

Figure 4.

Figure 4

Combination of SMI and cisplatin inhibition effect on expression levels of p-AKT, p-mTOR, and c-Myc in cisplatin-resistant A549/DDP cells and HIF-1α in cisplatin-resistant A549/DDP cells. (a) Western blot analysis of protein expression levels of AKT, p-AKT, mTOR, p-mTOR, c-Myc, and HIF-1α. (b) Quantification of relative protein expression levels of p-AKT, p-mTOR, c-Myc, and HIF-1α. The results represent the mean ± S.D. (n = 3); the experimental results are presented in triplicate. AKT: AKT serine/threonine kinase; mTOR: mechanistic target of rapamycin; p: phosphorylated; HIF-1α: hypoxia-inducible factor-1α; c-Myc: cellular-myelocytomatosis viral oncogene.