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SMI enhances cisplatin cytotoxicity in cisplatin-resistant A549/DDP cells via the AKT-mTOR-c-Myc signaling pathway. (a) LY294002 (PI3K inhibitor), (b) rapamycin (mTOR inhibitor), and (c) 10058-F4 (c-Myc inhibitor) were treated or not treated in cisplatin-resistant A549/DDP cells via western blot analysis of protein expression levels of genes involved in cell glucose metabolism.
