Table 7.
Gene-environment interaction models.
| Model | Training Bal | Testing Bal | CV consistency | P |
|---|---|---|---|---|
| Model 1a | ||||
| High-fat diet | 0.794 | 0.795 | 10/10 | 0.001∗ |
| High-fat diet/hypertension | 0.819 | 0.82 | 10/10 | 0.001∗ |
| Hypertension/high-fat diet/central obesity | 0.862 | 0.834 | 10/10 | 0.001∗ |
| rs1501299/hypertension/high-fat diet/central obesity | 0.862 | 0.835 | 9/10 | 0.001∗ |
| rs1501299/rs266729/hypertension/high-fat diet/central obesity | 0.883 | 0.851 | 9/10 | 0.001∗ |
| Gene-central obesity interactionb | ||||
| Central obesity | 0.64 | 0.639 | 10/10 | 0.001∗ |
| rs1501299/central obesity | 0.651 | 0.609 | 8/10 | 0.011∗ |
| rs266729/rs182052/central obesity | 0.671 | 0.605 | 7/10 | 0.011∗ |
| Gene–high-fat diet interactionc | ||||
| High-fat diet | 0.589 | 0.589 | 10/10 | 0.054 |
| rs10937273/rs1501299 | 0.607 | 0.478 | 5/10 | 0.377 |
| rs1501299/rs182052/high-fat diet | 0.638 | 0.461 | 4/10 | 0.989 |
| Gene–hypertension interactiond | ||||
| rs182052 | 0.565 | 0.474 | 4/10 | 0.828 |
| rs10937273/rs1501299 | 0.599 | 0.434 | 6/10 | 0.945 |
| rs10937273/rs1501299/rs266729 | 0.628 | 0.42 | 3/10 | 0.991 |
| Gene–drinking interactione | ||||
| rs1501299 | 0.563 | 0.498 | 5/10 | 0.945 |
| rs182052/rs2241767 | 0.584 | 0.448 | 5/10 | 0.945 |
| rs1501299/rs182052/rs2241767 | 0.612 | 0.462 | 5/10 | 0.945 |
Note: ∗P < 0.05.aAdjusted for age.bAdjusted for age, high-fat diet, hypertension, smoking, drinking, gender, BMI, and exercise.cAdjusted for age, central obesity, hypertension, smoking, drinking, gender, BMI, and exercise.dAdjusted for age, central obesity, high-fat diet, smoking, drinking, gender, BMI, and exercise.eAdjusted for age, central obesity, high-fat diet, hypertension, smoking, gender, BMI, and exercise.