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letter
. 2020 Jul;105(7):e349–e354. doi: 10.3324/haematol.2019.228775

Figure 1.

Figure 1

Changes of endoscopic features in cases of Helicobacter pylori -dependent gastric lymphomas treated with eradication therapy and time to complete remission and survival curves for patients. (A–H) Changes of endoscopic features in cases of Helicobacter pylori (HP)-dependent gastric diffuse large B-cell lymphoma [DLBCL mucosal-associated lymphoma tissue (MALT)] and MALT lymphoma before and after completion of HP eradication therapy (HPE). (A) Endoscopy showing an ulcerative mass in the angle in a 70-year old woman before HPE [histopathology disclosed DLBCL(MALT)]. (B) Endoscopic ultrasound (EUS) showing tumor with involvement of muscle layers (maximum thickness: 11 mm) in the same case, A#. Left bottom inset, hypoechoic lesions at the perigastric region (white arrow). (C) One month after completion of HPE, partial remission (PR) was achieved in the same case, A#. Right bottom inset, muscle layer involvement (maximum thickness: 7.6 mm) but no hypoechoic lesions at the perigastric region (D) Four months after completion of HPE, complete remission (CR) was achieved in the same case, A# (E) Endoscopy showing huge hyperemic patches with nodularity at the angle and antrum and one 0.5 cm shallow ulcer at the angle in a 76-year old woman before HPE (histopathology disclosed MALT lymphoma). (F) EUS showing the tumor with whole layer involvement (maximum thickness: 12.6 mm) in the same case, E# (G) One month after completion of HPE, PR was achieved in the same case, E#. Right bottom inset, whole layers with mild thickening (2.3 mm) (H) Seven months after completion of HPE, CR was achieved in the same case, E#. (I–K) Time to complete remission and survival curves for patients who received HPE as first-line treatment. (I) Time to CR in 34 cases [26 with MALT lymphoma (MALToma) and 8 with DLBCL(MALT)] was calculated from the completion of antibiotic treatment to the first evidence of CR through Kaplan-Meier analysis. (J) The overall survival (OS) curve for all cases according to the histological subclassification. (K) The relapse-free survival (RFS) curve for HP-dependent cases according to the histological subclassification.